It’s a difficult one, as you can’t optimise for everyone. However if someone is really so disabled that they can’t travel independently to the point that walking down a road is problematic then they are really going to struggle with Oxford St. today.

All the busses and taxis running down the middle of the road will prevent them from crossing to access all the other shops. They would probably be better off visiting one of the many other shopping areas rather than a tourist trap.